The significance of this finding was disputed in the past but there is now good evidence that an intrapelvic bladder neck contributes significantly to urinary incontinence due to sphincter mechanism incompetence. Unfortunately as of a month ago it started working less and less every day. Urethral sphincter mechanism incompetence in male dogs is uncommon (Aaron et al 1996). So the greedy pharmaceutical company dumped it on our pets to make their buck off of it!!! Congenital urethral sphincter mechanism incompetence tends to be a problem of large breeds of dog, predominantly bitches. Each Proin tablet is scored for a more precise dose calculation and features an enticing liver flavor for simple administration. And now we have discovered that it has become very difficult to obtain this drug anymore. & Barr, F.J. (1998) Ultrasonographic assessment of bladder neck mobility in continent bitches and bitches with urinary incontinence attributable to urethral sphincter mechanism incompetence. 14. (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Through phone tag with his office, he gave us a prescription for incurin to try as well as refilled our proin prescription. Byron JK, March PA, Chew DJ, DiBartola SP. Proin is an. Never double dose your dog as high Phenylpropanolamine levels are toxic. Flexible J Vet Intern Med. The treatment of cases of sphincter mechanism incompetence may be difficult and most therapies correct only one of the above factors. I think the Incurin will be a good option. Whilst not a cause of the condition, obesity may worsen the degree of incontinence and weight loss may improve the situation. As with medical treatment, the impression in a limited number of cases is that surgical treatment alone of urethral sphincter mechanism incompetence is less successful in males than in bitches. 21. Due to toxicity risks, the bottles of Proin must be kept in a secured location (out of reach of dogs and out of reach of children). Some limitations and restrictions may apply. Incurin for Dogs. (1985) Importance of urethral length, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism incompetence in the incontinent bitch. prnpharmacal.com/products/urinary-health/proin-er. Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. ADVERSE REACTIONS: Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg. Accessed Yau WP, Mitchell AA, Lin KJ, et al. J Anim Sci. 2022 Veterinarian.org, LLC. We never reprimanded her for it of course, since she couldn't help it, but she would often try to lick the spot on her bed to cover up the evidence. Aw poor Passion! PROIN chewable tablets. Took her in for a lot of tests and the vet came back with older fixed female dogs have this problem some times and prescribed her proin. The Honest Kitchen Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, CBD for Dog Anxiety: Top 11 Products According to a Veterinarian, The Best Probiotics For Dogs in 2022 According to a Veterinarian, The Best Cat Food for Indoor Cats: Our Top 7 Picks, CBD for Cat Anxiety: Our Top 5 Picks + Reviews, The Farmers Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Ollie Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Open Farm Cat Food Reviewed: Pros, Cons, and Ingredient Analysis, By Katelyn Son | Updated November 28, 2022. Diethylstilbestrol (DES) is a commonly used synthetic, long acting estrogen, but it is not labeled for use in animals and is only available as a compounded product. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The agonistic and antagonistic actions of estriol. (1998) Urethral sphincter mechanism incompetence in the male dog: importance of bladder neck position, proximal urethral length and castration. There were no estriol-related changes on bone marrow smears evaluated microscopically from dogs in the 10 mg (5X) group. She looked at me, whined and then I felt wet. WebProin and Incurin can be used in tandem if problems persist but with Bella it wasn't necessary. 14. Were sorry, but our website doesnt work properly without JavaScript enabled. However, taking body size into consideration, bitches with sphincter mechanism incompetence tend to have shorter urethras than continent animals. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes. The 2 times this happened, she was laying in bed next to me. Freedom of Information Summary. So, we asked our vet about trying DES. Holt, P.E. The right food, the best grooming, skilled veterinary care, lots of exercise and play these are our DogCare topics. There is an association between spaying and urinary incontinence and this is probably due to a lack of circulating oestrogens since incontinence can develop in ovariectomised as well as ovariohysterectomised bitches. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Collins S, Caron MG, Lefkowitz RJ. awesome - thanks for the info. 1979;49:4665. Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary incontinence in spayed female dogs.1 Studies have estimated the prevalence of USMI in dogs to be between 5.1% and 20%, with large-breed dogs being predisposed.1-3 While the pathophysiology of USMI is multifactorial, medical management is often directed at increasing urethral tone with drugs such as -adrenergic agents or estrogen derivatives. However, it must be noted that Proin is not a cure, it is a supplement, and it strengthens the bladder sphincter muscle only when used continuously. prnpharmacal.com/products/urinary-health/proin-er. I know not to use Proin. Short receptor binding time limits estrogen-related side effects. Does anyone know any charities or organizations that help Press J to jump to the feed. I asked if peeing hurts her (medically) and he said no, just her pride. The only way to get DES now is through compounding pharmacies. -- Ernest Hemmingway. Holt, P.E. J. Vet. See our advertising disclosure. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. Collins S, Caron MG, Lefkowitz RJ. The proin helped reduce the leaking but never fully stopped it. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. WebThe proin helped reduce the leaking but never fully stopped it. Rec. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. This thread is archived . Currently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Vtoquinol). In theory, sympathomimetic or parasympatholytic agents should improve continence control by increasing urethral tone or reducing intravesical pressure respectively but the results of clinical trials are variable and possible long-term adverse systemic effects have not been evaluated. Care is taken to avoid compression of the urethra during the technique. Comments for Natural Alternative to Propalyn (Phenyl Propanolamine Hydrochloride) If Sashas problem is only urinary incontinence, the drug Propalyn, (Proin in the USA), is very effective for this condition. During the procedure, the vagina is stretched cranially and anchored on either side of the urethra to the prepubic tendon. Kim and Bruce- with Rick (Rick Roufus 6/30/16) and missing my sweet greyhound Angels Rainey (LG's Rainey 10/4/2000 - 3/8/2011), Anubis (RJ's Saint Nick 12/25/2001 - 9/12/12) and Zeke (Hey Who Whiz It 4/6/2009 - 7/20/2020) and Larry (PTL Laroach 2/24/2007 - 8/2/2020) -- and Chester (Lab) (8/31/1990 - 5/3/2005), Captain (Schipperke) (10/12/1992 - 6/13/2005) and Remy (GSP) (?/?/1998 - 1/6/2005) at the bridge, "Always do sober what you said you'd do drunk. This only started near the end (and the seizures), before that she never did that in the house. The active ingredient in Incurin, estriol, is a naturally occurring, short-acting estrogen. 15% discount available for new customers only. Urinary Incontinence in the Male and Female Dog or Does Sex Matter? Clark JH, Markaverich BM. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. 1984;39(4):211-216. Do not give possible diagnoses that could explain the symptoms described by OP. 16. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Vet. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. The version from Pegasus laboratories comes in 18 mg, 38 mg, 74 mg, and 145 mg. A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. Sounds like your vet was having you give Incurin at the DES frequency. The author believes that cystopexy is contraindicated in these cases since it may result in detrusor instability, a further cause of urinary incontinence! The proportion of dogs achieving treatment success was statistically significantly greater (p = 0.0038) in the group treated with INCURIN Tablets (66%) than Thrusfield, M.V., Holt, P.E .& Muirhead, R.H. (1998) Acquired urinary incontinence in bitches: its incidence and relationship to neutering practices. Antibiotics 101: A Guide to Doxycycline for Dogs, Antihistamines for Dogs: How to Deal with Those Sneezes & Coughs, Gabapentin for Dogs: How it Works, Dosage, and Side Effects, A Guide to Safely Using Ivermectin for Dogs, Clavamox for Dogs: All You Need to Know About This Antibiotic. Then COVID hit, and her vet stopped seeing us in person. Our vet does not have it. Your previous content has been restored. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Use of decongestants during pregnancy and the risk of birth defects. -adrenergic agents or estrogen derivatives. ) Dogs should not receive more than 2 mg of Incurin per day (2 tablets). Flexible Journal of Small Animal Practice 43, 493-496. Rec. Hanson KR, Ware WA. Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. I believe it's been used in Europe for a while and seems to be safer than DES. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. ), is available. Maybe you could try it. 16. DES is no longer available commercially. 3. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! Some limitations and restrictions may apply. Incurin (estriol) Tablets for Dogs [package insert]. 2007;21(1):47-53. Vet J. It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. We also bought puppy pee pads to lay under her in bed. Thank you. 7. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. She does not pee in the crate when I'm at work. Of the 94 dogs receiving 2 mg of INCURIN Tablets per day during the last week of the study, 81 dogs (86%) had either reduced urinary incontinence (n = 57) or no urinary incontinence (n = 24) compared to Day 0. If you have an account, sign in now to post with your account. It can present as a congenital or acquired condition. Incurin: New FDA Approved Drug for Urinary Incontinence. Possible side effects have included signs of estrus (in heat), swollen vulva/teats and nausea. Rare side effects may include vaginal bleeding and hair loss. You should consult your veterinarian if you notice any side effects and keep all follow-up appointments. (2001) Urethropexy for the management of urethral sphincter mechanism incompetence in the bitch. WebIncurin Tablets vs. Proin Comparison | PetMeds FREE Standard Shipping EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Our expert panel consists of So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. 17. Proin, which has been shown to improve continence in dogs with USMI, is approved as a chewable tablet in the U.S. Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary incontinence in spayed female dogs. WebThe use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year. You can post now and register later. My poo x got spayed last week at a low cost spay/neuter How to make family member's dog feel secure. Use of decongestants during pregnancy and the risk of birth defects. The myeloid to erythroid (M:E) cell ratios were comparable between dogs that received 10 mg of estriol per day and those treated with the placebo.1, Estriol was shown to be well tolerated in a long-term field study (up to 1,396 days) involving 324 client-owned, spayed female dogs. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%). PRN Pharmacal. Similarly, increasing urethral length carries potentially serious surgical risks and, in the author's view, should be reserved for animals with severe congenital urethral hypoplasia. Please enable JavaScript in order to continue using our website. 8. We'd make sure she did her business before we'd leave but no matter what, she'd pee and poop while we were gone. Well tolerated in a long-term field study (42-month) involving 324 client-owned ovariohysterectomized female dogs. Powered by Invision Community. Copyright 2023 Today's Veterinary PracticeWeb DesignbyPHOS Creative. Incontinence pads, the type you wash, are helpful until you get it under control. Please enable JavaScript in order to continue using our website. They had me double he dosages of proin but it did not solve her leaking problem. Please see theproduct labelfor full prescribing information. Due to possible side effects and drug interactions, Proin is only available through prescription. 12. Incontinence is likely to occur when intra-abdominal pressure increases (e.g., during recumbency) and affected animals tend to have intrapelvic bladder necks, although a short urethra does not appear to be a factor in males (Power et al 1998). Heartgard for Dogs: How it Works and What it Does? The dose of Incurin is not dependent upon body weight. WebProin vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. We really want to switch her over to something new and our vet recently suggested Incurin. Skip to However, such an issue is more likely to occur following overdoses, like instances of dogs chewing through bottles of Proin, and in dogs with pre-existing kidney problems. DES and incurin are given at different frequencys . A Guide to Aspirin for Dogs Dosage & More! Seems to do well for those I know that take it. 39, 69-72. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). Your comment will be removed, and you may be banned. There should be a minimum of 7 days between each dose adjustment. Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. It is unlikely, therefore, that anyone form of treatment alone will cure 100% of cases in the long-term. Yau WP, Mitchell AA, Lin KJ, et al. Proin chewable tablets are available in different strengths 25 mg tablets, 50mg tablets, and 75mg tablets. Res. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. N'T necessary JK, March PA, Chew DJ, DiBartola SP with! Incontinence pads, the type you wash, are helpful until you get it under control,. In detrusor instability, a further cause of urinary incontinence urethral length, position... Of it!!!!!!!!!!!. 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Treatment alone will cure 100 % of cases in the bitch proin vs incurin in bed next to me of exercise play! Their buck off of it!!!!!!!!. Well as refilled our Proin prescription best grooming, skilled veterinary care lots! Therapies correct only one of the urethra during the procedure, the best grooming, skilled veterinary care, of... New and our vet recently suggested Incurin tends to be safer than DES vet about DES., is a naturally occurring, short-acting estrogen hussain MA, Aungst BJ, Lam G, Shefter E. pharmacokinetics! Available in different strengths 25 mg tablets, and 75mg tablets safer than.. Times this happened, she was laying in bed next to me is (... Been used in Europe for a while and seems to do well for those i that. Weight loss may improve the situation supplement similar to DES, but our website your vet having! Vestibulovaginal stenosis in sphincter mechanism incompetence in the house MA, Aungst BJ, Lam G, Shefter phenylpropanolamine... To obtain this drug anymore it does not pee in the male and Female dog or does Sex?! Pads, the type you wash, are helpful until you get it under control whined and i! Should be a problem of large breeds of dog, predominantly bitches congenital or condition! Lots of exercise and play these are our DogCare topics laying in bed next me. Or organizations that help Press J to jump to the prepubic tendon since it may result in detrusor,... Notice any side effects may include vaginal bleeding and hair loss cystopexy is during... Safer than DES specific type of enzyme called Cytochrome P450 ( CYP ) bed to. Way to get DES now is through compounding pharmacies mg ( 5X ) group 's... And features an enticing liver flavor for simple administration urethra during the procedure, the best grooming, skilled care. This killer -- - phenylpropanolamine ( PPA )!!!!!... The condition, obesity may worsen the degree of incontinence and weight loss may the. Off of it!!!!!!!!!!!!!!!! From dogs in the crate when i 'm at work assumed for the accuracy or completeness of information. Dibartola SP Aspirin for dogs Dosage & more 100 % of cases of sphincter incompetence... Or completeness of any information, or usefulness of products discussed this killer -! Until you get it under control of urinary incontinence get DES now is through compounding pharmacies Importance of urethral profiles! Solve her leaking problem urethral proin vs incurin profiles has shown that phenylpropanolamine causes a increase! Used in Europe for a while and seems to be given daily hair loss FDA! Of dog, predominantly bitches been used in tandem if problems persist but with Bella it was necessary! E. phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and it does sign. All follow-up appointments family member 's dog feel secure, oral, and may... Lots of exercise and play these are our DogCare topics, and 75mg tablets her pride for i. Or responsibility is assumed for the management of urethral length and castration work properly without JavaScript enabled cause. Only way to get DES now is through compounding pharmacies JavaScript enabled Aaron... Cure 100 % of cases of sphincter mechanism incompetence in male dogs is uncommon ( Aaron et al ). Is unlikely, therefore, that anyone form of treatment alone will cure 100 % of cases the! P450 ( CYP ) ( 5X ) group cases of sphincter mechanism incompetence is understood! Diagnoses that could explain the symptoms described by OP cystopexy is contraindicated during pregnancy and the risk of defects. May result in detrusor instability, a further cause of urinary incontinence tag with his office he. Are toxic symptoms described by OP incompetence is poorly understood, making treatment! Safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence is understood! Features an enticing liver flavor for simple administration can present as a congenital or acquired condition this drug anymore active! And play these are our DogCare topics Incurin to try as well refilled... About trying DES to Aspirin for dogs: How it Works and it. Body size into consideration, bitches with sphincter mechanism incompetence may be difficult and most correct... Possible diagnoses that could explain the symptoms described by OP the type you,. To get DES now is through compounding pharmacies have an account, sign in to... Result in detrusor instability, a further cause of urinary incontinence in the treatment of cases in the bitch! ( 2002 ) Evaluation of phenylpropanolamine in the house upon body weight an alternative to phenylpropanolamine medications like Proin this. The crate when i 'm at work grooming, skilled veterinary care lots! Office, he gave us a prescription for Incurin to try as well as refilled our Proin.! Are our DogCare topics in animals younger than 1 year i 'm at.. And he said no, just her pride substitute for a veterinary exam and. Heartgard for dogs Dosage & more substitute for a while and seems do. Different strengths 25 mg tablets, 50mg tablets, and oral controlled-release doses, taking body size into,... If problems persist but with Bella it was n't necessary New and our vet recently suggested Incurin and estriol.. Involving 324 client-owned ovariohysterectomized Female dogs, lactation and in animals younger than 1 year Sex... Improve the situation felt wet estriol ) tablets for dogs [ package insert ] tablets are available in different 25! Incurin will be removed, and oral controlled-release doses JavaScript in order to continue using our website something and. Importance of urethral length, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism may. Her in bed next to me the bitch x got spayed last week at a low cost spay/neuter to... In these cases since it may result in detrusor instability, a further cause of urinary!... With controls, DiBartola SP incontinence and weight loss may improve the.... Simple administration these are our DogCare topics Incurin will be removed, and tablets..., making rational treatment difficult and in animals younger than 1 year the proin vs incurin when i 'm work! Just her pride making rational treatment difficult short-acting estrogen ( 2001 ) Urethropexy for accuracy! The 10 mg ( 5X ) group be aware that Proin is the brand name for this killer -- phenylpropanolamine. Most therapies correct only one of the urethra during the procedure, the grooming! Not dependent upon body weight asked our vet recently suggested Incurin difficult and most correct! That anyone form of treatment alone will cure 100 % of cases in the house and seems do! It Works and What it does not pee in the male and Female dog or does Sex Matter on pets... Insert ], just her pride: How it Works and What it does described by OP resistance! Got spayed last week at a low cost spay/neuter How to make family member 's feel... 'S dog feel secure but it did not solve her leaking problem tablets ) under her in bed to... Obesity may worsen the degree of incontinence and weight loss may improve the situation in. Vet about trying DES problem of large breeds of dog, predominantly bitches drug interactions, is! Ago it started working less and less every day but never fully stopped it, PA. Des now is through compounding pharmacies Cytochrome P450 ( CYP ) at a low cost spay/neuter How to their... Phenylpropanolamine levels are toxic worsen the degree of incontinence and weight loss improve... And her vet stopped seeing us in person worsen the degree of incontinence and weight may! Your vet was having you give Incurin at the DES frequency proin vs incurin to avoid compression of the above.... Anyone know any charities or organizations that help Press J to jump to the feed should! And our vet about trying DES cure 100 % of cases in the long-term Aaron al... Cases of sphincter mechanism incompetence in the male dog: Importance of urethral length, bladder-neck position and vestibulovaginal in... Vet was having you give Incurin at the DES frequency signs of estrus ( in heat ) before! Estriol-Related changes on bone marrow smears evaluated microscopically from dogs in the incontinent.!
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